Cellulite a condition where collections of fat push against the connective tissue, causing cosmetically unacceptable lumpy, dimpled appearance of skin resembling cottage cheese. A cellulite mesotherapy treatment requires at least 3 months’ time. In treating cellulite, for better clinical results, it is important to use a combination of different techniques, including mesotherapy. To be effective, these techniques have to work first on the extra cellular matrix, the microcirculation (arteriolar, capillary, venous) and the lymphatic system, and finally, on the fat tissue.